D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction

Cell Reports, 2021

In Brief: SARS-CoV-2 spike undergoes large conformational changes during cell fusion. Gobeil et al. identify a subdomain anchor that limits large motions in the receptor binding subunit of the pre-fusion spike from propagating to its fusion subunit. They demonstrate that theD614G mutation increases the rate off urin cleavage, which may impact infectivity.

Jackson ImmunoResearch´s Peroxidase-AffiniPure Goat Anti-Human IgG, Fc gamma Fragment Specific JIM-109-035-098 was used in this study.