NONO (Non-POU Domain-Containing Octamer-Binding Protein, Non-POU Domain Containing, Octamer-Binding), Rabbit
Artikelnummer:
USB-487031
- Bilder (0)
| Artikelname: | NONO (Non-POU Domain-Containing Octamer-Binding Protein, Non-POU Domain Containing, Octamer-Binding), Rabbit |
| Artikelnummer: | USB-487031 |
| Hersteller Artikelnummer: | 487031 |
| Alternativnummer: | USB-487031-100 |
| Hersteller: | US Biological |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | IF, WB |
| Immunogen: | Synthetic peptide corresponding to the N-terminal region of human NONO |
| NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Applications: Suitable for use in Immunofluorescence, Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
Produktgarantie und fachkundiger Support
