COT, EST, ESTF, TPL2, AURA2, MEKK8, Tpl-2, c-COT, MAP3K8
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases,