Tcell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP1.CD5 may act as a receptor in regulating Tcell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL10. Development,selection and function of different B and Tcell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5like molecules. - Proteine/Peptide
