Synthesized peptide derived from the Internal region of human MLH1. Location: 410-490aa.
Alternative Synonym:
FCC2, COCA2, HNPCC, hMLH1, HNPCC2, MMRCS1
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ph