BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T
The biological activity of human BCA-1 was determined by chemotaxis assay using human B cells. Significant chemotaxis was achieved at a concentration range of 1.0-10 ng/ml.
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