Selective inhibitor of IRE1alpha ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1alpha and inactivating both XBP1 splicing and IRE1alpha-mediated mRNA d
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten