The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene th
Reconstitute with 20mM Tris (pH8.0) and 150mM NaCl to 0.1-1.0mg/ml. Do not vortex. Lyophilized from 20mM Tris (pH8.0), 150mM NaCl, 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose, ProClin 300.
Expression System:
E. coli
Formulierung:
Lyophilized powder
Sequenz:
N-terminal His-Tag, Glu20~His242 (NP_001153467.1)
Anwendungsbeschreibung:
NRG1 (neuregulin-1) is a membrane glycoprotein that belongs to the neuregulin family and act on the EGFR family of receptors. It mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. It is reporte
SDS-PAGE analysis of GTX00417-pro Human Neuregulin-1 protein (active).
Cell proliferation effect of GTX00417-pro Human Neuregulin-1 protein (active) on MCF-7 cells. After incubation of Human Neuregulin-1 protein (active) for 72 hrs, cell proliferation was measured by Cell Counting Kit-8 (CCK-8). The ED50 for this effect is typically 5.240 to 9.112 ng/ml.
Cell proliferation effect of GTX00417-pro Human Neuregulin-1 protein (active). (A) Unstimulated MCF-7 cells cultured in DMEM for 72hrs. (B) MCF-7 cells cultured in DMEM, stimulated with 10 ng/ml NRG1 for 72hrs.
GTX00417-pro Image
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