A recombinant human MDM2 protein fragment (within amino acids 1-300) was used as the immunogen for the MDM2 antibody.
E3 ubiquitin-protein ligase Mdm2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of
