Purified recombinant prokaryotic full-length human p16INK4a protein was used as the immunogen for the recombinant CDKN2A antibody.
p16INK4a is a tumor suppressor protein. It is a specific inhibitor of cdk4/cdk6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16INK4a gene revealed homozygous deletions, nonsense, missense, or