4E Binding Protein 1, non-phosphorylated (Thr46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP), Clone: [7H187D12], Rabbit, Monoclonal

Produktübersicht

• Artikelname: 4E Binding Protein 1, non-phosphorylated (Thr46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP), Clone: [7H187D12], Rabbit, Monoclonal
• Artikelnummer: USB-0004-20B
• Hersteller Artikelnummer: 0004-20B
• Alternativnummer: USB-0004-20B-100
• Hersteller: US Biological
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: FC, IF, WB
• Immunogen: Synthetic peptide corresponding to residues surrounding Thr46 of human 4E-BP1.

Produktbeschreibung

4E-BP1 (also known as PHAS-1) when bound to eIF4E, inhibits cap-dependent translation. Upon hyperphosphorylation of 4E-BP1 this interaction is disrupted and cap-dependent translation is activated (1). Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [7H187D12]
• Reinheit: Purified
• Formulierung: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 0.02% sodium azide, 50% glycerol.