Ptf1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PTF1A.
Ptf1a is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. This protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in the Ptf1a gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. Applications: Suitable for use in ELISA, Western Blot Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:50-100 Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
