RNF7, Recombinant, Human, aa2-113, His-Tag (RING-box Protein 2)

Produktübersicht

• Artikelname: RNF7, Recombinant, Human, aa2-113, His-Tag (RING-box Protein 2)
• Artikelnummer: USB-375079
• Hersteller Artikelnummer: 375079
• Alternativnummer: USB-375079-20,USB-375079-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. Source: Recombinant protein corresponding to aa2-113 from human RNF7, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~14.5kD Amino Acid Sequence: ADVEDGEETCALASHSGSSGSKSGGDKMFSLKKWNAVAMWSWDVECDTCAICRVQVMDACLRCQAENKQEDCVVVWGECNHSFHNCCMSLWVKQNNRCPLCQQDWVVQRIGK Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 14.5
• UniProt: Q9UBF6
• Reinheit: ~85% (SDS-PAGE)
• Formulierung: Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.