ICOSLG, also known as ICOS ligand isoform a, is a number of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. This protein is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells. Its dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. Source: Recombinant protein corresponding to aa19-256 from human ICOSLG, fused to hIgG-His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~53.7kD (480aa), 50-70kD (SDS-PAGE under reducing conditions.) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: ADPDTQEKEV RAMVGSDVEL SCACPEGSRF QDEQKFHCLV LSQSLGFQEV LSVEVTLHVA LYDVVSVLRI ARTPSVNIGC CIENVLLQQN PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KTISKAKGQP REPQVYTLPP SRDELTKNQV SCSVMHEALH NHYTQKSLSL SPGKHHHHHH DLNDVYVYWQ TSESKTVVTY HIPQNSSLEN VDSRYRNRAL MSPAGMLRGD FSLRLFNVTP ANFSVPVVSA PHSPSQDELT FTCTSINGYP RPNVYWINKT DNSLLDQALQ NDTVFLNMRG LTVGSQTGND IGERDKITEN PVSTGEKNAA TLEPKSCDKT HTCPPCPAPE LLGGPSVFLF KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
