Ncr1, as known as natural cytotoxicity triggering receptor 1, is a natural killer cell p46-related protein. This protein, along with NKp30 and NKp44, are activiting receptors that belongs to the natural cytotoxicity receptor family. These receptors are expressed by NK cells in the peripheral blood and spleen expresses NKp46 in both resting and activated states. Also, it may contribute to the increased efficiency of activated NK cells to meditate tumor cell lysis. Description: Recombinant protein corresponding to aa17-256 of mouse Ncr1, fused to hIgG-His-Tag at the C-terminus, expressed in insect cell. Molecular Mass: Calculated: 54.4kD (481aa) Observed: 50-70kD (SDS-PAGE under reducing conditions.) Amino Acid Sequence: ADLQRINTEK ETLPKPIIWA KPSIMVTNGN SVNIWCQGAQ SASEYQLYFE GSFFALERPK PSRSMNKVRF FISQMTSHTA GIYTCFYQSG ELWSKSSNPL KLVVTGLYDT PNLWVYPRPE VTLGENVTFF CQLKTATSKF FLLKERGSNH IQNKYGNIQA EFPMGPVTRA HRGTYRCFGS YNDYAWSFPS EPVTLLITGG VENSSLAPTD PTSSLDYWEF DLSTNESGLQ KDSAFWDHTT QNLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
