LAMP2, also known as lysosome-associated membrane glycoprotein 2 isoform A, is a major component of lysosomal membranes. It provides selectins with carbohydrate ligands. This protein mediates the lysosomal uptake of the chaperone HSC73 in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles. Deficiency of LAMP2 is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. Recombinant human LAMP2 protein, fused to His-Tag at C-terminal, expressed in insect cell and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa29-375 of human LAMP2, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~39.4kD (356aa), ~57-70kD (SDS-PAGE under reducing conditions.) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: ADPLELNLTD SENATCLYAK WQMNFTVRYE TTNKTYKTVT ISDHGTVTYN GSICGDDQNG PKIAVQFGPG FSWIANFTKA ASTYSIDSVS FSYNTGDNTT FPDAEDKGIL TVDELLAIRI PLNDLFRCNS LSTLEKNDVV QHYWDVLVQA FVQNGTVSTN EFLCDKDKTS TVAPTIHTTV PSPTTTPTPK EKPEAGTYSV NNGNDTCLLA TMGLQLNITQ DKVASVININ PNTTHSTGSC RSHTALLRLN SSTIKYLDFV FAVKNENRFY LKEVNISMYL VNGSVFSIAN NNLSYWDAPL GSSYMCNKEQ TVSVSGAFQI NTFDLRVQPF NVTQGKYSTA QDCSADDDNF HHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
