UBR1 (E3 Ubiquitin-Protein Ligase UBR1, Ubiquitin Protein Ligase E3 Component N-recognin 1), Rabbit
Artikelnummer:
USB-495078
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| Artikelname: | UBR1 (E3 Ubiquitin-Protein Ligase UBR1, Ubiquitin Protein Ligase E3 Component N-recognin 1), Rabbit |
| Artikelnummer: | USB-495078 |
| Hersteller Artikelnummer: | 495078 |
| Alternativnummer: | USB-495078-100 |
| Hersteller: | US Biological |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Immunogen: | Synthetic peptide corresponding to the N-terminal region of human UBR1 |
| UBR1 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR1 may be involved in pancreatic homeostasis.The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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