SARS-CoV-2 Cell Entry Is Blocked by a Clinically Proven Protease Inhibitor

CELL, 2020

As described in their recent Cell study, Hoffmann et al. identified the serine protease TMPRSS2 as a critical factor in the priming of the SARS-CoV-2 spike protein with its receptor ACE2, and demonstrated that a clinically proven protease inhibitor, camostat mesylate, is able to interfere with SARS-CoV-2 infection of lung cells.

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