Recombinant active enzymes

Biologically-active human recombinant proteins from SignalChem

SignalChem is a biotechnology company focused on the research, development and production of innovative cell signaling products for the advancement of basic life sciences research and drug discovery efforts.

Specific emphasis is placed on the production of highly purified biologically-active human recombinant proteins. As a leader in the recombinant protein market, SignalChem produces products to fulfill the needs of scientists in both academia and the biotech industry. All of SignalChem’s products are subjected to rigorous testing and quality control analyses to ensure, that the highest quality proteins are produced.

 

SignalChem's range of active recombinant enzymes consists of kinases, phosphatases, epigenetic enzymes, ubiquitin enzymes & proteins, arginie deiminase, GTPases & ATPases, phosphodiesterases, and other enzymes.

 

KINASES

Protein Kinases are a family of pivotal enzymes with 518 members implicated in various cell signaling pathways, constituting over 2% of the human genome. Kinases exert their roles by phosphorylating their respective physiological substrates. They catalyze the transfer of γ-phosphate from ATP or GTP to the hydroxyl groups of serine, threonine and tyrosine residues on the substrate proteins or the glycosyl moieties in lipids. Deregulation of Kinase could lead to the changes in enzymatic activity and/or expression, subcellular localization, the stability of kinase, protein-protein interactions. Aberrant regulation of Kinase-mediated signaling pathways is responsible for all major human pathological conditions such as cancer, cardiovascular disease, neurodegenerative diseases and metabolic disorders.

SignalChem offers a broad range of recombinant protein and lipid Kinases of superior purity and activity to assist the global academic research and drug discovery efforts with the focus on Kinases. Its active Kinase product line is one of the most comprehensive in the world in terms of the coverage and has been utilized by many pharmaceutical companies in their drug discovery programs. An in-house product development team with over 100 years of combined experience in Kinase biochemistry is behind the production and quality control of all the Kinase-related products as well as assay development.

 

PHOSPHATASES

Protein phosphorylation is a reversible post-translational modification carried out by two families of enzymes, Protein Kinases and Protein Phosphatases. The interplay between these two families of enzymes is responsible for modulating the phosphorylation state of their physiological substrates, and thereby their activities, subcellular localization and interactions with other proteins. Similar to Protein Kinases, Protein Phosphatases play pivotal roles in a myriad of biological processes including cell growth, proliferation, survival, and apoptosis. Protein Phosphatases are broadly categorized according to specific amino acids they dephosphorylate into two major families: protein serine/threonine phosphatases, and protein tyrosine phosphatases, which also include the dual-specificity phosphatases.

SignalChem, with comprehensive active Protein Kinase product line, has utilized our expertise in the recombinant protein production to manufacture biologically active phosphatases including PP1s, PP2s, PTPNs, and more. An in-house product development team with over 100 years of combined experience in protein biochemistry is behind the production and quality control of all the phosphatases as well as the method development for their activity assays. We aim to manufacture our phosphatases with superior quality and activity to facilitate and assist the global research and drug discovery efforts aiding human health.

 

G PROTEINS

G Proteins, short for Guanine nucleotide-binding proteins, are a vital class of signaling molecules that play a central role in transmitting extracellular signals to the interior of cells. They act as molecular switches, converting information from various receptors on the cell surface to intracellular responses. G Proteins are involved in a wide range of physiological processes, including but not limited to cell growth, differentiation, metabolism, neurotransmission, immune response, and sensory perception. They are critical components of signal transduction pathways, which allow cells to respond appropriately to external stimuli and maintain homeostasis. Dysregulation of G Protein signaling has been implicated in numerous diseases, including cancer, cardiovascular disorders, neurological conditions, and metabolic disorders. Therefore, studying G proteins and their associated pathways is crucial for understanding disease mechanisms and identifying potential therapeutic targets.

Signalchem manufactures high-quality G proteins such as GTPases, ATPases, G protein alpha subunits, Ras, Rac, and Rho. We understand the importance of reliable research tools, and that’s why we ensure the utmost quality and performance of our G Protein products. With our dedication to customer satisfaction, you can trust that you are receiving proteins of the highest integrity and consistency, enabling you to achieve accurate and reproducible results.