Anti-Llama Secondary Antibodies

Monoclonal and polyclonal secondary antibodies from SouthernBiotech

SouthernBiotech offers both monoclonal and polyclonal anti-llama secondary antibodies for detecting the various Ig heavy chain classes and IgG subclasses as well as IgG(H+L) and VHH.

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Why Anti-Llama Antibodies?

Camelids produce conventional immunoglobulins (Igs) consisting of two heavy and two light chains as well as IgG heavy chain only antibodies (HcAbs) that have a simpler structure. The antigen binding domain of each HcAb heavy chain, known as the VHH region, has a molecular weight of just 15 kDa and can be produced recombinantly to provide several important advantages for scientific research. Critically, due to their small size, VHH antibodies can more easily penetrate cells and tissue samples during applications such as intracellular flow cytometry and immunohistochemistry (IHC). VHH antibodies also have high solubility and thermostability and are more amenable to engineering than conventional immunoglobulins.

SouthernBiotech anti-llama secondary antibodies are extensively characterized, affinity-purified polyclonal or monoclonal antibodies with specificities to the llama immunoglobulin heavy chain classes and subclasses as well as IgG (H+L). Anti-llama secondary antibodies are produced in goat and mouse. They are valuable in the detection of VHH antibodies and are available in a variety of formats including unconjugated and enzyme, biotinylated, and fluorescent conjugates for assays such as ELISA, western blot, flow cytometry, multiplex, and immunohistochemistry.

Since monoclonal antibodies will bind a single epitope on the antibody target, they are highly specific and deliver superior lot-to-lot consistency. Polyclonal anti-llama secondary antibodies can provide improved sensitivity through signal amplification as multiple secondary antibodies can bind to a single primary antibody. SouthernBiotech offer a broad selection of polyclonal and monoclonal anti-llama antibodies, all produced and validated in-house, for use in your VHH development.

 

	Fig 1: ELISA plate was coated with purified llama IgG1, IgG2/IgG3, IgM, and a VHH antibody. Immunoglobulins were detected with Mouse Anti-Llama IgG2/IgG3 (Cat. No. SBA-5880-01L) followed by Goat Anti-Mouse IgG2b, Human ads-HRP (Cat. No. SBA-1090-05).
	Fig 2: Llama IgG and llama serum was resolved by electrophoresis, transferred to PVD membrane, and probed with Mouse Anti-Llama IgM (Cat. No. SBA-5820-01L) followed by Goat Anti-Mouse IgG2b Human ads-HRP (Cat. No. SBA-1090-05) and chemiluminescent detection.

 

Available Anti-Llama Secondary Antibodies from Southern Biotech

Description	Clone	Cat. No.	Qty
Mouse Anti-Llama IgG1-UNLB	SB182L	SBA-5870-01L	1.0 mg
		SBA-5870-01M	0.5 mg
		SBA-5870-01S	0.1 mg
Mouse Anti-Llama IgG1-AP		SBA-5870-04	1.0 mL
Mouse Anti-Llama IgG1-HRP		SBA-5870-05	1.0 mL
Mouse Anti-Llama IgG1-BIOT		SBA-5870-08	0.5 mg
Mouse Anti-Llama IgG2/IgG3-UNL	SB183e	SBA-5880-01L	1.0 mg
		SBA-5880-01M	0.5 mg
		SBA-5880-01S	0.1 mg
Mouse Anti-Llama IgG2/IgG3-AP		SBA-5880-04	1.0 mL
Mouse Anti-Llama IgG2/IgG3-HRP		SBA-5880-05	1.0 mL
Mouse Anti-Llama IgG2/IgG3-BIOT		SBA-5880-08	0.5 mg
Mouse Anti-Llama IgM-UNLB	SB189b	SBA-5820-01L	1.0 mg
		SBA-5820-01M	0.5 mg
		SBA-5820-01S	0.1 mg
Mouse Anti-Llama IgM-AP		SBA-5820-04	1.0 mL
Mouse Anti-Llama IgM-HRP		SBA-5820-05	1.0 mL
Mouse Anti-Llama IgM-BIOT		SBA-5820-08	0.5 mg
Goat Anti-Llama IgG(H+L)-UNLB	Polyclonal	SBA-6045-01	1.0 mg
Goat Anti-Llama IgG(H+L)-FITC		SBA-6045-02	1.0 mg
Goat Anti-Llama IgG(H+L)-AP		SBA-6045-04	1.0 mL
Goat Anti-Llama IgG(H+L)-HRP		SBA-6045-05	1.0 mL
Goat Anti-Llama IgG(H+L)-BIOT		SBA-6045-08	1.0 mg
Goat Anti-Llama IgG(H+L)-AF488		SBA-6045-30	1.0 mg
Goat Anti-Llama IgG(H+L)-AF647		SBA-6045-31	1.0 mg

 

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