Absolute Antibody
Engineered Antibodies for All
Absolute Antibody was founded in 2012 with a vision to make engineered recombinant antibodies accessible to all. It remains the only company 100% focused on recombinant antibody technology. Though recombinant antibodies are standard in the pharmaceutical industry, these antibodies have not been as widely available for diagnostics or research. This is starting to change, however, due to the many advantages recombinant antibodies offer over traditional hybridoma-produced monoclonal antibodies.
Absolute Antibody specializes in antibody sequencing, engineering and recombinant expression, offering royalty-free custom services and a unique reagents catalog of engineered recombinant antibodies and Fc Fusion proteins. Customers include leading pharmaceutical, biotechnology and diagnostics companies, as well as academic researchers worldwide. This international customer base is served by an ISO 9001:2015-certified manufacturing facility in Northeast England.
Advantages of using recombinant antibodies:
- Ensured reproducibility Recombinant antibodies are defined by amino acid sequence, ensuring reliant reproducibility.
- Biological definition Recombinant antibodies are truly biologically defined, with no variation in heavy or light chains.
- High purity Expression in a chemically defined, serum-free mammalian expression system.
- Added antibody value Recombinant antibodies can be engineered into new formats for new experimental possibilities.
- Animal-free manufacturing in vitro production using synthetic genes in an entirely animal-free process.
- Security Unlike hybridomas, recombinant antibodies are not susceptible to contamination, genetic drift or accidental loss.
Antibody engineering options include:
- Switching to different species, isotypes and subtypes
- Creating antibody fragments, bispecifics and trispecifics
- Developing chimeric and humanized antibodies
- Producing Fc Silent™ versions to reduce non-specific staining
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