Daresbury Proteins

Authentic mammalian proteins for high-end applications

Daresbury Proteins Ltd specializes in mammalian recombinant protein production and cell line development which can be transferred into a third party’s cGMP setting.

Focussed on quality, Daresbury Proteins offers a catalogue of histidine-tagged recombinant human proteins for research, clinical and diagnostic applications.
Products include a range of fibroblast growth factor receptor (FGFR) proteins, vascular adhesion protein-1 (VAP-1) and amyloid precursor proteins (APP), which can be transferred into a client’s cGMP setting. The products, originally custom manufactured for university-based scientists; at the time were mostly unavailable elsewhere. As a result, the recombinants have been used in cutting-edge functional studies in academic research, as rare antigens to generate highly specific antibodies and to produce ground-breaking data.

Using proprietary vector technology to obtain difficult-to-express recombinant proteins with uncompromising quality; their novel high-yield stable mammalian expression vector system can increase protein expression by up to 50-fold when compared to alternative mammalian-based production systems. This superior expression system produces recombinant human proteins in human
cell lines resulting in highly active, authentic proteins without contamination by viral genetic elements. Making the resulting highly stable proteins especially suitable for clinical applications. The system can generate stable rapid pools 5-9 days after transfection for most proteins, without the need for additional clonal selection and expansion, saving both time and money. The expression platform is also able to handle larger proteins in the 50-200 kDa range.

Daresbury Proteins bring to their academic and industrial partners extensive knowledge, relating to expression of a wide range of product classes including those that are difficult to express, development of research cell lines and production of candidate targets.
Daresbury Proteins can quickly generate custom stable cell lines producing a protein of interest, rivalling the timescale of a transient recombinant production approach, of weeks as opposed to months, yet offers rapid scalability for larger-scale production.
 

Product Range:

• Recombinant proteins from mammalian cells, with fully authentic post-translational modifications and glycosylation profile, giving a functionally superior performance compared to proteins produced in Chinese Hamster Ovary cells (CHO).
• Full length/large soluble proteins, possessing full activity and immunogenic properties.
• Histidine-tagged recombinant proteins for detection without interfering with protein function. Fc-tagged recombinants due to their larger size may affect the protein’s performance leading to artefacts, abolished function, or reduced activity.
• Recombinant protein production service

https://www.daresburyproteins.co.uk/

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