ILite TNF-alpha
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| Article Name: | ILite TNF-alpha |
| Biozol Catalog Number: | EUD-BM3044 |
| Supplier Catalog Number: | BM3044 |
| Alternative Catalog Number: | EUD-BM3044 |
| Manufacturer: | Svar Life Science |
| Category: | Humandiagnostik |
The iLite® TNF-alpha Assay Ready Cells provide a means of directly quantifying both the potency and neutralizing antibody response to TNF-alpha antagonists of diverse structure in the same assay, making it an outstanding tool for biosimilar development. Measuring the functional activity of TNF-alpha, the assay can be used for both potency and immunogenicity assessments of TNF-alpha inhibitors in the same assay and the iLite TNF-alpha assay ready cells also provide a means of directly comparing a biosimilar and innovator product in the same assay. The iLite TNF-alpha cells are engineered cells for use in a normalized reporter gene bioassay for screening of anti-TNF alpha activity in samples. The assay is a simple and easy test format which detects anti-TNF alpha activity and, indirectly, the presence of anti-drug antibodies. iLite TNF-alpha cells are a genetically engineered reporter gene cell line of human origin (K562), responsive to tumor necrosis factor alpha (TNF-alpha), resulting in the specific expression of Firefly Luciferase. Normalization of cell counts and serum matrix effects is obtained by a second reporter gene, a Renilla Luciferase reporter gene construct, under control of a constitutive promotor. FOR RESEARCH USE ONLY |
| Form: | Assay Ready Cells |
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