Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRbeta, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1alpha by inhibiting autophosphorylation and consequent RNase activation[2].
Molecular Weight:
398.47
Purity:
99.69
CAS Number:
[557795-19-4]
Formula:
C22H27FN4O2
Target:
Apoptosis,Autophagy,IRE1,Mitophagy,PDGFR,VEGFR
Application Notes:
MCE Product type: Reference compound
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