Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS & SPR verified), Unconjugated

Product Overview

• Article Name: Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS & SPR verified), Unconjugated
• Biozol Catalog Number: ABS-IT7-H52W4-1MG
• Supplier Catalog Number: IT7-H52W4-1mg
• Alternative Catalog Number: ABS-IT7-H52W4-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the ECadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyers patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV1 virus in the gutassociated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD). - Proteine/Peptide

Product Properties

• Molecular Weight: 111.4 kDa (ITGA4) & 83.7 kDa (ITGB7)
• Tag: C-10*His | Native
• NCBI: 13612
• Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
• Purity: 90%
• Form: Powder
• Target: Integrin alpha 4 beta 7

Images

Immobilized Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) at 2 µg/mL (100 µL/well) can bind Monoclonal Anti-Human ITGA4&ITGB7 Antibody, Human IgG4 with a linear range of 0.1-2 ng/mL (Routinely tested).

Immobilized Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) at 1 µg/mL (100 µL/well) can bind Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) with a linear range of 0.2-4 ng/mL (Routinely tested).

Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

IT7-H52W4-1mg