This protein A purified monoclonal antibody was produced by repeated immunizations with recombinant human PMS2 corresponding to the first 133 amino acid residues of the protein. The clone was produced using conventional hybridoma technology.
PMS2 is a highly conserved nuclear protein involved in mismatch repair during DNA replication and has been identified to be composed as a heterodimer of PMS2 and MLH1. PMS is part of the BRCA1-associated genome surveillance complex (BASC), which contains
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Purity:
This is an protein A purified antibody from ascites fluid directed against PMS2-134 and reacts with full length version of PMS2 in human and hamster tissues. The epitope was putatively mapped to amino acids 58-81 of human PMS2. BLAST analysis indicates t
Application Notes:
Anti-PMS2 antibody has been tested for use in ELISA and western blotting. This product is suitable for immunoprecipitation. Specific conditions for western blotting reactivity should be optimized by the end user. Expect a band approximately 96 kDa in siz
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