Anti-Transthyretin 56-61, amyloid specific (mouse monoclonal), IgG1, Monoclonal
Biozol Catalog Number:
AGR-AS16-3113
Supplier Catalog Number:
AS16-3113
Alternative Catalog Number:
AGR-AS16-3113
Manufacturer:
Agrisera
Host:
Mouse
Category:
Antikörper
Application:
ELISA, IHC, WB
Species Reactivity:
Human
Immunogen:
Recombinant protein corresponding to the Human wild type Transthyretin. GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE The epitope has been mapped to residue 56-61
Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal
Clonality:
Monoclonal
Molecular Weight:
155
Isotype:
IgG1
Purity:
Affinity purified in PBS pH 7.4.
Form:
Lyophilized
Antibody Type:
Monoclonal Antibody
Application Dilute:
1:1000 (ELISA), 1:500 (IHC), 1:1000 (WB)
Application Notes:
Specifically reactive to the amyloid form of human Transthyretin. Epitope mapped to residue 56-61 which remains buried within the native fold of transthyretin but becomes exposed within its amyloid form.It has been suggested that that two distinct mechan
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