AMG 232 is an extremely potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC50 = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg).
Molecular Weight:
568.55
Purity:
>99%
CAS Number:
[1352066-68-2]
Formula:
C28H35Cl2NO5S
Target:
Mdm2
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