SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. In acute myeloid leukemia (AML) cell lines, the IC50 range is about 500 nm-1 µM. Ski-178 induces apoptosis of human acute myeloid leukemia cells in a CDK1-dependent manner.
Molecular Weight:
394.42
Purity:
>98%
CAS Number:
[1259484-97-3]
Formula:
C21H22N4O4
Target:
SPHK
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