Abrocitinib is an orally active and selective JAK1 inhibitor with an IC50 value of 29 nM. Abrocitinib reversibly inhibits JAK1 kinase by blocking its ATP-binding site. Abrocitinib (PF-04965842) inhibited TYK2 activity (IC50, 1.253 µM) and phosphorylation
Molecular Weight:
323.41
Purity:
>99%
CAS Number:
[1622902-68-4]
Formula:
C14H21N5O2S
Target:
JAK
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