E.coli-derived human MCAK recombinant protein (Position: G531-Q725). Human MCAK shares 87% amino acid (aa) sequence identity with both mouse and rat MCAK.
Alternative Names:
CT139,kinesin-like protein 6,kinesin-like protein KIF2C,KNSL6,MCAK,mitotic centromere-associated kinesin,testis tissue sperm-binding protein Li 68n.
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:190608
