E.coli-derived human MSH2 recombinant protein (Position: Q337-N583). Human MSH2 shares 94% and 93% amino acid (aa) sequence identity with mouse and rat MSH2, respectively.
Alternative Names:
COCA1,DNA mismatch repair protein Msh2,DNA mismatch repair protein Msh2 transcript,FCC1,hMSH2,HNPCC,HNPCC1,LCFS2,MMRCS2,mutS homolog 2, colon cancer, nonpolyposis type 1,MutS protein homolog 2.
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, hetero