Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
The monoclonal antibody was affinity-purified from Syrian Hamster antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Syrian Hamster IgG. Liquid in PBS, pH 7.3, and 0.02% sodium azide.
Application Dilute:
IF (1/50 - 1/200)
Application Notes:
Recognizes mouse CD152
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