ssPalmE

Product Overview

• Article Name: ssPalmE
• Biozol Catalog Number: ECH-N-1018-10MG
• Supplier Catalog Number: N-1018-10MG
• Alternative Catalog Number: ECH-N-1018-10MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

ssPalmE is an ionizable lipid for delivering plasmid DNA into cells via forming lipid nanoparticles (LNPs).

Additional Information

Background

ssPalmE is an ionizable lipid for delivering plasmid DNA into cells via forming lipid nanoparticles (LNPs). The disulfide-cleavable lipid is pH-sensitive and responsive to the intracellular environment. Delivery of pDNA encoding the solute form of VEGFR suppressed tumor growth in a mouse model with OS-RC-2 tumors (renal cell carcinoma).

References

Hidetaka Akita, et al “A neutral lipid envelop-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma” J. of Contr. Release, 2015, 200:97-105.

 

Additional Information

Molecular Formula: C78H132N2O10S2

MW: 1322.04

CAS: n/a

Alternative Names: O,O'-(((disulfanediylbis(ethane-2,1-diyl))bis(methylazanediyl))bis(propane-3,1-diyl)) bis(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-yl) disuccinate

Solubility: ~5 mg/mL in ethanol, >10 mg/mL dichloromethane.

Storage and Handling: Store dry at -20 0C, Stock solutions should be stored frozen (-20 0C or below).

Images

ECH-N-1018