Selective for B-Raf against 46 other kinases. SB 590885 dihydrochloride decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E.
Molecular Weight:
539
Purity:
98% (HPLC)
CAS Number:
[405554-55-4]
Formula:
C27H27N5O2 . HCl
Target:
B-Raf, Erk
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