Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of p
Molecular Weight:
485.9
Purity:
95% (HPLC)
CAS Number:
[850140-72-6]
Formula:
C24H25ClFN5O3
Target:
EGFR, ErbB-2, ErbB-4
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