98% by TLC [ 5% methanol in methylene chloride, Rf = 0.35] NMR conforms
Form:
White solid
CAS Number:
[118414-82-7]
Formula:
C27H34ClNO2S
Application Notes:
Inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. Also inhibits PPARalpha (80% inhibition at 10 µM).3
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