98% by TLC [ 2% CH3OH in CH2Cl2, Rf = 0.25] NMR Conforms
Form:
Off-white solid
CAS Number:
[393514-24-4]
Formula:
C20H25ClN4O
Application Notes:
Vanilloid receptor I (TRPV1) antagonist, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Displays analgesic activity in rat models of neuropathic pain. Orally active and cell permeable.
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