98% by TLC [ 10% methanol in methylene chloride, Rf = 0.50] NMR Conforms
Form:
Tan solid
CAS Number:
[133550-30-8]
Formula:
C17H14N2O3
Application Notes:
A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL c
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