Zileuton is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50s = 400nM rat PMNL, 400nM human PMNL and 900nM human whole blood).1 Zileuton suppressed pro
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