98% by TLC [10% Methanol in methylene chloride, Rf = 0.60] NMR Conforms
Form:
White solid
CAS Number:
[55224-94-7]
Formula:
C11H12ClNO
Application Notes:
TRPA1 channel blocker IC50=3.1-4.5 µM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M
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