98% by TLC [5% methanol in methylene chloride, Rf = 0.37] NMR Conforms
Form:
Pale yellow solid
CAS Number:
[4311-88-0]
Formula:
C13H13N3OS
Application Notes:
Necrostatin-1 is an inhibitor of necroptosis (non-apoptotic cell death pathway, EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2 It displays a protective effect in a mouse model
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