Gue1654 is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicosanoid2. It selectively inhibits Gbetagamma but not Galphai signaling upon activation of the Galphai-betagamma heterotrimer by OXE-R.1,3 Gue1654
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