EHNA inhibits phosphodiesterase 2 (PDE2) (IC50 = 0.8 - 5.5 µM in a variety of tissues and species) over PDE1, PDE3, or PDE4 (IC50 values > 100 µM).1,2 It also inhibits adenosine deaminase (ADA), IC50 = 1.2 and 1.5 µM in human RBCs and astrocytoma cells,
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