Crizotinib, CAS [[877399-52-5]]

Product Overview

• Article Name: Crizotinib, CAS [[877399-52-5]]
• Biozol Catalog Number: FBM-10-2626
• Supplier Catalog Number: 10-2626
• Alternative Catalog Number: FBM-10-2626-5MG,FBM-10-2626-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: PF-02341066, PF-1066

Product Description

c-Met and ALK inhibitor

Product Properties

• Molecular Weight: 450.34
• Purity: 98% by HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [877399-52-5]
• Formula: C21H22Cl2FN5O

Application Notes

• Application Notes: A potent and selective inhibitor of c-MET and ALK, IC50s=8 and 20 nM respectively.1 Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC50=30 nM) but not in ALK-negati