AMG 510, CAS [[2296729-00-3]]

Product Overview

• Article Name: AMG 510, CAS [[2296729-00-3]]
• Biozol Catalog Number: FBM-10-3930
• Supplier Catalog Number: 10-3930
• Alternative Catalog Number: FBM-10-3930-5MG,FBM-10-3930-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Sotorasib

Product Description

Covalent KRASG12C Inhibitor

Product Properties

• Molecular Weight: 560.61
• Purity: >98% by HPLC , NMR (Conforms)
• Form: White solid
• CAS Number: [2296729-00-3]
• Formula: C30H30F2N6O3

Application Notes

• Application Notes: AMG 510 is a potent (IC50s = 6 nM NCI-H358, 9 nM MIA PaCa-2) covalent KRASG12C inhibitor.1,2 It significantly inhibited tumor growth in NCI-H358 and MIA PaCa-2 cell lines as well as CT-26 tumors (mouse syngeneic model) and caused tumor regression at hig