RU.521, CAS [[2262452-06-0]]

Product Overview

• Article Name: RU.521, CAS [[2262452-06-0]]
• Biozol Catalog Number: FBM-10-4140
• Supplier Catalog Number: 10-4140
• Alternative Catalog Number: FBM-10-4140-5MG,FBM-10-4140-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

cGAS inhibitor

Product Properties

• Molecular Weight: 415.23
• Purity: 98% by TLC NMR (Conforms)
• Form: Off-white to pale pink solid
• CAS Number: [2262452-06-0]
• Formula: C19H12Cl2N4O3

Application Notes

• Application Notes: Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 IC50 = 0.70 µM in dsDNA-stimulated RAW macrophages1 and ~0.80 µM in wild type human THP-1 cells2. It is selective for cGA