7-Cl-O-Nec1, CAS [[852391-15-2]]

Product Overview

• Article Name: 7-Cl-O-Nec1, CAS [[852391-15-2]]
• Biozol Catalog Number: FBM-10-4544
• Supplier Catalog Number: 10-4544
• Alternative Catalog Number: FBM-10-4544-5MG,FBM-10-4544-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Nec-1s, Necrostatin1-S

Product Description

Rip1 blocker

Product Properties

• Molecular Weight: 277.71
• Purity: 98% by TLC (5% methanol / methylene chloride, Rf = 0.55), NMR (Conforms)
• Form: Yellow solid
• CAS Number: [852391-15-2]
• Formula: C13H12ClN3O2

Application Notes

• Application Notes: Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O