Necrostatin-34, CAS [[375835-43-1]]

Product Overview

• Article Name: Necrostatin-34, CAS [[375835-43-1]]
• Biozol Catalog Number: FBM-10-4684
• Supplier Catalog Number: 10-4684
• Alternative Catalog Number: FBM-10-4684-5MG,FBM-10-4684-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Nec-34, 2-((3-Cyano-6-oxo-4-(p-tolyl)-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide

Product Description

RIP1 kinase inhibitor

Product Properties

• Molecular Weight: 384.47
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [375835-43-1]
• Formula: C18H16N4O2S2

Application Notes

• Application Notes: Necrostatin-34 is a selective inhibitor of RIP1 kinase. IC50s = 667 nM and 134 nM for TNFalpha in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 (Focus Cat 10-4544) locking the enzyme in an inact