Adavosertib, CAS [[955365-80-7]]

Product Overview

• Article Name: Adavosertib, CAS [[955365-80-7]]
• Biozol Catalog Number: FBM-10-4823
• Supplier Catalog Number: 10-4823
• Alternative Catalog Number: FBM-10-4823-5MG,FBM-10-4823-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: MK-1775, AZD1775

Product Description

Wee1 kinase inhibitor

Product Properties

• Molecular Weight: 500.61
• Purity: >98% by TLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [955365-80-7]
• Formula: C27H32N8O2

Application Notes

• Application Notes: Inhibits Wee1 tyrosine kinase (IC50 = 5.2 nM) thus preventing phosphorylation of CDC2 and abrogating the G2 DNA damage checkpoint, sensitizing a variety of tumor cells to DNA damaging agents.1 Adavosertib also blocks Wee1 phosphorylation of E3 ubiquitin